![]() LVP showed a similar pattern, with a tendency of decreased pressure at low doses, and an increased pressure at high doses (P < 0.05). All doses of adrenaline increased heart rate, while BP showed a biphasic response: At low doses, adrenaline decreased SBP from 118 +/- 3 to 106 +/- 4 mm Hg (n = 15 P < 0.05) and DBP from 86 +/- 3 to 71 +/- 3 (n = 15 P < 0.05), while at high doses, SBP and DBP increased. Finally, we tested the hemodynamic effect of salbutamol in a subset of pigs. Second, we determined the response to adrenaline (0.3 mu g/kg) after atropine, prazosin, and propranolol pretreatment. ![]() First, we tested the dose-dependent effects of adrenaline (0.01-10 mu g/kg). Pigs were anesthetized, intubated, and electrocardiogram, systolic BP (SBP), diastolic BP (DBP), and left ventricular pressure (LVP) were monitored continuously. Nineteen Danish landrace pigs were used to pharmacologically probe the hemodynamic effect of adrenaline. ![]() We aimed to determine the dosedependent effects of adrenaline on hemodynamics and to test whether adrenaline could lower blood pressure (BP) through a beta(2)-adrenergic pathway. Although general vasoconstriction to nonessential tissues is imperative, the vasodilatory effect of beta-adrenergic receptor activation contends with this. ![]() Adrenaline (epinephrine) is one of the prime messengers of the fight-or-flight response, favoring the activation of beta-adrenergic receptors. ![]()
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